The Alzheimer's Solution

The Alzheimer's Solution

A Breakthrough Program to Prevent and Reverse the Symptoms of Cognitive Decline at Every Age

Book - 2017
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"Based on the largest clinical and observational study to date, neurologists and codirectors of the Brain Health and Alzheimer's Prevention Program at Loma Linda University Medical Center, Drs. Dean and Ayesha Sherzai, offer in The Alzheimer's Solution the first comprehensive program for preventing Alzheimer's disease and improving cognitive function. Alzheimer's disease isn't a genetic inevitability, and a diagnosis does not need to come with a death sentence. Ninety percent of us can avoid ever getting Alzheimer's, and for the 10 percent with strong genetic risk for cognitive decline, the disease can be delayed by ten to fifteen years. This isn't an estimate or wishful thinking; it's a percentage based on rigorous science and the remarkable results the Sherzais have seen firsthand in their clinic. This much-needed revolutionary book reveals how the brain is a living universe, directly influenced by nutrition, exercise, stress, sleep, and engagement. In other words: what you feed it, how you treat it, when you challenge it, and the ways in which you allow it to rest. These factors are the pillars of the groundbreaking program you'll find in these pages, which features a personalized assessment for evaluating risk, a five-part program for prevention and symptom-reversal, and day-by-day guides for optimizing cognitive function."--
Publisher: New York, NY :, HarperOne,, [2017]
Edition: First edition
Copyright Date: ©2017
ISBN: 9780062666475
0062666479
Branch Call Number: 616.83 SHE 2017
Characteristics: 352 pages : illustrations ; 24 cm
Additional Contributors: Sherzai, Ayesha

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gaetanlion
Nov 26, 2017

The Alzheimer’s solution: Excellent on numerous counts with a couple of caveats. The authors, two qualified neurologists, have developed an empirical and scientific based approach to reducing and preventing the symptoms of Alzheimer’s disease. I read this book fairly shortly after reading the equally excellent “The End of Alzheimer’s” by Dale Bredesen. As can be expected both respective authors/books approach to managing and reducing the risk of Alzheimer’s Disease (AD) overlap a lot. Their approaches are based on healthy lifestyle modifications.
While Bredesen is mainly focused on nutrition and fasting, the Sherzais have a more multidimensional approach including also exercise, meditation, sleep, and building cognitive reserves (exercising your brain).
The Sherzais are also really strong in explaining the different causal mechanisms that cause AD including: 1) oxidation; 2) inflammation; 3) glucose dysregulation; and 4) lipid dysregulation. By contrast, Bredesen is mainly focused on inflammation. He also mentioned inadequate nutritional and hormonal support to the brain as a second factor and toxicity (mercury, etc.) as a third factor. However, on this count I do find the Sherzais explanation of AD much more thorough from a physiological standpoint.
There is one chapter where one has to express reservation, and it is the one on nutrition. They stick to a low fat, low cholesterol mantra relying on the research by Ancel Keys dating back to 1951. We now know his research was highly biased, and his conclusion very much wrong. Extensive scientific rebuttals have been disclosed in numerous books. Probably the best one on the subject is Uffe Ravnskov’s “The Cholesterol Myth” published in 1999. But, other current books also hammer away on the fallacies of Keys’ studies, including Dr. Mercola’s “Fat for Fuel” among many others. In view of the Sherzais diverging views on nutrition, they constantly warn against the profound ill impact of saturated fats and eggs (cholesterol). Well, in both cases they are deemed inaccurate by many other neurologists and nutritionist experts much concerned about overall health and the health of the brain. In this camp you will find not only Ravnskov and Mercola, but also Dale Bredesen, and Steven Gundry (the author of “The Plant Paradox”).
Saturated fats are associated with numerous health benefits including enhancing absorption of numerous vitamins and minerals, boosting HDL levels (the good cholesterol), enhancing mitochondria energy metabolism, contributing to brain health (the brain does need much fat to function).
Another area where the Sherzais impart questionable information is concerning the overall risk of AD. On page 22, they indicate that if you have no ApoE4 genes, you have a 50% risk of developing AD by 85 years old. 23andme, a genetic testing company, relying on a very large sample of Caucasians, discloses an AD risk that is more than 5 x lower than the Sherzais. They come up with a risk of 5-8% for men and 6-10% for women. The Framingham Study comes up with an overall risk of AD (that does not exclude individuals that have the ApoE4 genes) by 85 years old of 12% for men and 20% for women.

t
tjdickey
Oct 12, 2017

With support in lifestyle research and personalized medicine, the authors report from their work at the Brain Health center at Loma Linda University Medical Center on a plan for reducing the risk, and sometimes even reversing the early symptoms of, cognitive decline. The plan involves personalized approaches to healthy living for people of all ages, with benefits even from small and incremental changes: Nutrition in a healthy and whole-food diet, Exercise spread throughout the day where possible, Unwinding from stress through relaxation and social support, Restorative sleep, and Optimizing brain function by engaging it in activities such as music and learning languages, and in meaningful social interaction. Helpful supplements to the text include personalized questionnaires, diet, meditation and exercise guides, and even a set of brain-friendly recipes.

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