"A Plague on Both Your Houses" introduces physician Matthew Bartholomew, whose unorthodox but effective treatment of his patients frequently draws accusations of heresy from his more traditional colleagues. Besides his practice, Bartholomew teaches medicine at Michaelhouse, part of the fledgling University of Cambridge. In 1348, the inhabitants of Cambridge live under the shadow of a terrible pestilence that has ravaged Europe and is traveling relentlessly towards England. Bartholomew, however, is distracted by the sudden and inexplicable death of the Master of Michaelhouse, a death University authorities do not want investigated. His pursuit of the truth leads him into a complex tangle of lies and intrigue that forces him to question the innocence of his closest friends, even his family. And then the Black Death finally arrives.